Lecture 'IL-1 and TNF interdependence in mounting protective immunity to M.tuberculosis'
Dmitry M. Shayakhmetov (David C. Lowance Chair of Human Immunology, Lowance Center for Human Immunology, Emory Children's Center for Transplantation and Immune Mediated Disorders, Division of Rheumatology, Departments of Pediatrics and Medicine, Emory University, Atlanta, USA) will present his recent work on M. Tuberculosis and immunity.
Interleukine-1 (IL-1) and tumor necrosis factor (TNF) are key inflammatory cytokines with pleiotropic functions. In response to infection with bacterial and viral pathogens, both IL-1 and TNF become activated and play critical and non-redundant roles in mounting protective host responses. Although much attention has been given to date to dissecting individual roles of these cytokines in host defense and as drivers of human pathology, the molecular basis for their interdependence remained poorly understood. We will present and discuss the molecular model of IL-1-dependent control of TNF function in the context of chronic and progressive M.tuberculosis infection.