The Laboratory of Pharmaceutical Technology offers the following scientific services :

• formulation of dosage forms (tablets, granules, solutions, suspensions, emulsions, creams, freeze-dried products, …), including production at lab-scale using the following techniques : granulation (low- en high-shear), compression, extrusion-sferonisation, hot-stage extrusion, coating (fluid-bed), freeze-drying, …
• characterisation of solid dosage forms (powders, granules, tablets, pellets) :
  - in-vitro dissolution (USP methods 1, 2 and 3)
  - hardness, friability and desintegration time of tablets (Eur. Pharm.)
  - compression properties of drugs and excipients (using an excentric press and compaction simulator)
  - bioadhesion test of tablets

• physical characterization of materials
  - flow properties of powders and granules (Eur. Pharm.)
  - particle size distribution (sieve analysis and laserdiffraction)
  - thermal analysis (Differential Scanning Calorimetry)
  - water content (IR-oven, Karl Fischer titration)
  - viscosity
  - pH-determination
  - bulk and tapped volume
  - true density (He-pycnometry)
  - pore size distribution (Hg-porosimetry)

• development and optimalisation of freeze-drying cycles
• steam sterilisation

For more information :

Prof. Dr. Chris Vervaet
Phone : +32 (0)92648069