Dr. ir. Ashish Kumar

BIOMATH, Model-based analysis and optimisation of (bio)processes
Department of Mathematical Modelling, Statistics and Bioinformatics

Coupure Links 653Dr. ir. Ashish Kumar
B-9000 Gent (Belgium)
Tel.: +32-9-264.59.37
Fax: +32-9-264.62.20
E-mail:
Website: http://users.ugent.be/~ashishku/
Education: Process engineer

Obtained degree of Doctor in Applied Biological Sciences in 2015

Development of predictive knowledge platform on tabletability for solid dosage manufacturing (PreTAP)

Objectives

  • Understanding the impact of changes in the formulation design space/powder characteristics/process conditions on the Finite element analysis (FEA) prediction of compaction.
  • Primary feasibility study to evaluate the application of discrete element method (DEM) approach for powder compaction simulation.

Background

    • The most common drug product dosage form is tablet (over 90% of the drug product).
    • Development of robust tableting process in a timely manner is still challenging due to lacking fundamental understanding of the process.
    • Application of sophisticated process simulation tools can improve mechanistic understanding of the tableting process.

                Continuous tableting              Compaction Simulator
                              Continuous tableting                                             Compaction Simulator

Methodology

  • Obtain the necessary inputs for FEA based on DPC model (Young Modulus, Poisson ratio, cohesion (d), friction angle (β), cap eccentricity (R)) using compaction simulator.
  • Carry out FEA simulation for different formulations and punch shape.
  • Develop a statistical/mathematical method to quantify goodness of FEA prediction (based on comparing the FEA result and X-Ray CT scan in terms of relative density).

 

            Model Output                   Axisymmetric FE model-2D