Samata Mehta

Samata Mehta

Contact info:

Samata Mehta
Laboratory of Pharmaceutical Technology
Harelbekestraat 72, B-9000 Gent (Belgium)
Tel: +32 (0)9 264 80 68
E-mail: Samata.Mehta@UGent.be

Title of research project:

Formulation of starch multi particulate system for vaginal delivery

Summary:

Vaginal administration enables the use of prolonged dosing regimens, lower daily doses, and continuous release of medication. Drugs avoid gastrointestinal (GI) absorption and the hepatic first-pass effect. The vagina is often an ideal route for drug administration because it allows for the administration of lower doses, steady drug levels, and less frequent administration than the oral route. It is preferable for the drug to be distributed rapidly throughout the vaginal space, as might be the case for an anti-infective treatment. The currently available Vaginal Delivery formulations have limitations, such as leakage, messiness and low residence time, which contribute to poor patient and /or product compliance. Conventional solutions, semisolids (ointments, creams, and some gels), tablets, and pessaries all suffer from problems of retention and spreadability when used intravaginally. Semisolids, in particular, are perceived as messy in use and prone to leakage. Conventional systems do not offer sufficient flexibility in design with respect to controlling the drug release rate and sustaining release over periods extending from days to, perhaps, months. A cost-benefit analysis is essential in deciding upon the choice of delivery system. Of course the Pellet formulation technique involves less capital as compared to vaginal rings or fabricated elastomeric devices.

So, the multi particulates may be promising formulations for delivery of drugs to the vagina with good spreadability, long retention and effective drug release with better patient compliance.

Aim of research work:

Recognizing that the therapeutic delivery of the active agent plays a critical role in the overall success of therapy, and attempting to circumvent the weaknesses of traditional vaginal drug delivery while maintaining and even improving safety profiles, a new form of vaginal drug delivery will be developed.

So, the aim of present research will be, to design and characterize the starch based multi particulate system for vaginal delivery; intended for long retention of formulation by adhesion to vaginal mucosa, proposed for anti infective/anti HIV/microbicides drug delivery. It will be a novel approach for the better treatment of vaginal diseases.