APRICOT

Anesthesia Practice In Childeren Observational Trial

APRICOT is a prospective observational multicenter cohort study, designed to identify the incidence and potential risk factors of severe critical events in children undergoing anesthesia in Europe. The present trial also aims to describe the differences in pediatric anesthesia practice throughout Europe, to study the potential impact of the variability on the occurrence of those severe critical events and to improve the quality and safety of anesthesia in children throughout Europe.
During a 2 week inclusion period, the project aims to include all children from birth to 15 years old, scheduled for an elective or urgent diagnostic or surgical procedure under sedation or general anesthesia with or without regional analgesia or under regional anesthesia.
Primary endpoint is the occurrence of selected severe critical events which will be recorded during and up to 60 minutes after anesthesia or sedation, requiring immediate intervention.
These severe critical incidents include: Laryngospasm, Bronchospasm, Pulmonary aspiration, Drug error, Anaphylaxis, Cardiovascular instability, Neurological damage, Perianaesthetic cardiac arrest and postanaesthetic Stridor (in PACU).
The secondary endpoint is represented by the risk factors and the consequences for the occurrence of these severe critical events including in-hospital mortality established up to 30 days or at discharge.

  • Chief Investigator : Prof. Walid Habre (Geneva University Children ‘s Hospital)
  • Sponsor : ESA Clinical Trial Network
  • National Coordinator : Prof. Dr. F. Veyckemans (UCL)
  • Investigators UZ Gent : Prof. Dr. S. De Hert, Dr. J. Huys
  • Timeline : a 2 week inclusion period between March 15th 2014 and December 31th 2014
  • Clinical Trial.gov identifier : NCT 01878760