Study HES

Effect of Hydroxyethyl Starch 6% 130/0.4 in a balanced electrolyte solution (Volulyte®) compared to gelatine (Geloplasma®) on microvascular reactivity and tissue oxygen saturation during haemodilution measured with near-infrared spectroscopy.

The aim of this study is to compare 6% hydroxyethyl starch (HES) 130/0.4 in a balanced electrolyte solution (Volulyte®, Fresenius Kabi, Schelle, Belgium) with modified fluid gelatin (Geloplasma®, Fresenius Kabi, Schelle, Belgium) as the priming solution for the cardiopulmonary bypass (CPB) circuit. The microvascular reactivity and the effects on tissue (StO2) and cerebral (ScO2) oxygen saturation will be examined using near-infrared spectroscopy (NIRS). Microvascular reactivity will be evaluated with postocclusive reactive hyperemia (PORH).

The primary outcome variable is the StO2 recovery slope (recStO2) after postocclusive ischaemia.
Secondary outcome variables are ScO2, StO2 , blood gas analyses, haemodynamics, urinary output and use of vasoactive medication during CPB.

  • Investigators UZ Gent : Dr. A. Moerman, Prof. Dr. S. De Hert, , Dr. K. François, Prof. Dr. F. De Somer, Dr. C. Van Eeckhout
  • Timeline : start inclusion February 2014, 1 year
  • Clinical Trial.gov identifier : NCT02034682