Cardiologie
Medewerkers
Staf:
Postdoctorale medewerkers:
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Onderzoeksprojecten
The Asklepios project is an epidemiological project that started between 2002 and 2004 in an intense collaberation with the GP’s practice Asklepios (Erpe Mere and Nieuwerkerken) and the Ghent University. The four partners at teh University are: the department of Internal Medicine (cardiology), the department of Public Health, the department of Civil Engineering and the department of Molecular Biotechnology. The primary interest of the Asklepios project is successful ageing, cardiac and vascular haemodynamics. Two thousand five hundred healthy people between the age of 35 and 55 filled in questionnaires, had an extensive examination of their blood, DNA, antropometrical, non-invasive cardiac and vascular parameters.
This group of people is followed up as a cohort. The cross-sectional connections are currently processed and published. In 2010, after 7 years, the second measuring round of the Asklepios project will start and this second round is expected to be completed in 2014. The follow-up is vital to validate conceptual insights on disease processes, by documenting the progression. The final phase of the study will be outcome analyses that will focuse on major adverse cardiac events (MACE). In this second round further collaboration will be developed with endocrinology (J.M. Kaufman), kidney disease (R. Vanholder) and lung disease (G. Brusselle, G. Joos).
Belangrijkste publicaties
Chirinos JA, Segers P, Gupta AK, Swillens A, Rietzschel ER, De Buyzere ML, Kirkpatrick JN, Gillebert TC, Wang Y, Keane MG, Townsend R, Ferrari VA, Wiegers SE, St John SM. Time-varying myocardial stress and systolic pressure-stress relationship: role in myocardial-arterial coupling in hypertension. Circulation 2009;119:2798-2807.
De Meyer T, Rietzschel ER, De Buyzere ML, Langlois MR, De Bacquer D, Segers P, Van Damme P, De Backer GG, Van Oostveldt P, Van Criekinge W, Gillebert TC, Bekaert S. Systemic telomere length and preclinical atherosclerosis: the Asklepios Study. Eur Heart J 2009;30:3074-3081.
Langlois MR, Rietzschel ER, De Buyzere ML, De Bacquer D, Bekaert S, Blaton V, De Backer GG, Gillebert TC. Femoral plaques confound the association of circulating oxidized low-density lipoprotein with carotid atherosclerosis in a general population aged 35 to 55 years: the Asklepios Study. Arterioscler Thromb Vasc Biol 2008;28:1563-1568.
Rietzschel ER, Langlois M, De Buyzere ML, Segers P, De Bacquer D, Bekaert S, Cooman L, Van OP, Verdonck P, De Backer GG, Gillebert TC. Oxidized low-density lipoprotein cholesterol is associated with decreases in cardiac function independent of vascular alterations. Hypertension 2008;52:535-541.
Rietzschel ER, De Buyzere ML, Bekaert S, Segers P, De Bacquer D, Cooman L, Van Damme P, Cassiman P, Langlois M, Van Oostveldt P, Verdonck P, De Backer G, Gillebert TC. Rationale, design, methods and baseline characteristics of the Asklepios Study. Eur J Cardiovasc Prev Rehabil 2007;14:179-191.
Segers P, Rietzschel ER, De Buyzere ML, Vermeersch SJ, De Bacquer D, Van Bortel LM, De Backer G, Gillebert TC, Verdonck PR. Noninvasive (input) impedance, pulse wave velocity, and wave reflection in healthy middle-aged men and women. Hypertension 2007;49:1248-1255.
Doctoraten
- Ernst R. Rietzschel: Asklepios study, successful cardiovascular aging. Novel biomarkers, lifestyle and early cardiovascular damage in the general population. (Promotor: Thierry Gillebert, Co-promotor: Dirk De Bacquer)
- Peter Gheeraert: Ventricular fibrillation during acute myocardial infarction: From patient and infarction characteristics to risk factors and risk estimates. (Promotor: Thierry Gillebert)
Samenwerkingsverbanden
- Framingham Heart Study (Mitchell, Levy, US)
- Rotterdam study (Witteman, NL)
- University of Pennsylvania (Chirinos, St.John-Sutton, US)
- Vesalius Research Centre Leuven (Lambrechts, Carmeliet, BE)
- Grace Registry (Keith Fox, Van de Werf, BE)
- ARIC study (Folsom, US)
- University of Hannover (Drexler, Wollert, DE)
- University of Lyon (Derumeaux, FR)
