Laboratory of Intensive Care Outcomes Reasearch



Prof. dr. Johan Decruyenaere

Prof. dr. Eric Hoste

Prof. dr. Dominique Benoit

Prof. dr. Jan De Waele

Prof. dr. Pieter Depuydt

Prof. dr. Kirsten Colpaert

Dr. Patrick Druwé


Wetenschappelijke medewerkers:

Annick de Jaeger

Carl Roosens

Ann Verstraete


Outcomes research focuses on the effects of medical care on individuals and society. To address its questions, outcomes research relies on a variety of disciplines including clinical epidemiology, medical informatics, health economics and advanced biostatistical modeling including artificial intelligence techniques. The Laboratory of Intensive Care Outcomes Research is organized in separate but closely interactive cells to achieve synergistic research results.

Onderzoeksproject 1: Acute kidney injury in the ICU

Under management of E. Hoste, in collaboration with R. Vanholder (Dpt. of Nephrology) and J. Kellum (Pittsburgh, USA)

Onderzoeksproject 2: Impact of Intensive Care information technology and decision support on the quality of care

Under management of J. Decruyenaere, in collaboration with F. De Turck (dept of Information Technology, Ghent University).

Onderzoeksproject 3: Longitudinal data analysis, time series analysis and causality in the ICU

Under management of D. Benoit, P. In collaboration with S. Vansteelandt (Dept of Applied Mathematics and Computer Science, Ghent University) and JF Timsit (University of Grenoble, France)

Onderzoeksproject 4: Severe abdominal pathology in the ICU (acute pancreatitis, abdominal hypertension and severe abdominal infections)

Under management of J. De Waele, in collaboration with Ph. Duyck, L. Delrue (Dept of Radiology, Ghent) and M. Malbrain (Stuyvenberg Hospital, AZN, Antwerp)

Onderzoeksproject 5: Infectiology in Critical Care Medicine

Under management of P. Depuydt, in collaboration with D. Vogelaers (Dept of Infectiology) and G. Claeys (Dept of Microbiology)

Onderzoeksproject 6: Sepsis, inflammation, ischemia/reperfusion injury

Under management of J. Decruyenaere and D.Benoit

Onderzoeksproject 7: Health economics in the ICU

Under management of J. Decruyenaere, in collaboration with L. Annemans (Dept of Public Health, UGent)

Onderzoeksproject 8: Prognosis of hemato-oncological patients in the ICU

Under management of D. Benoit, in collaboration with F. Offner (Dept. of Hematology, Ghent), E. Azoulay (Paris, France), M.Soares (Rio de Janeiro, Brazil)

Onderzoeksproject 9: End-of-life issues and communication in the ICU

Under management of D. Benoit in collaboration with N. Van Den Noortgate (Dept of Internal Medicine) and E. Azoulay (Paris, France)

Beschikbare onderzoekstechnieken en -infrastructuur

Clinical trial cell (3 study nurses) with 24h/24h 7d/7d coverage for patient inclusion and follow-up

Intensive Care Information System: a dedicated patient data management system where on average 16,000 patient data are collected and stored per patient and per day

Belangrijkste publicaties

RIFLE criteria for acute kidney injury are associated with hospital mortality in critically ill patients: a cohort analysis. Eric AJ Hoste, Gilles Clermont, Alexander Kersten, Ramesh Venkataraman, Derek C Angus, Dirk De Bacquer and John A Kellum. Critical Care 2006, 10.

Impact of computerized physician order entry on medication prescription errors in the intensive care unit: a controlled cross-sectional trial. Kirsten Colpaert, Barbara Claus, Annemie Somers, Koenraad Vandewoude, Hugo Robays and Johan Decruyenaere. Critical Care 2006, 10.

Excess risk of death from ventilator associated pneumonia: a reappraisal using longitudinal causal analysis. Bekaert M, Timsit, J, Decruyenaere, J, Garrouste-Orgeas, M, Azoulay, E, Goldgran-Toledano, D, Vansteelandt, S, Benoit, D. Intensive Care Med 2009; 35, 16.

Results from the international conference of experts on intra-abdominal hypertension and abdominal compartment syndrome. I. Definitions. Malbrain ML, Cheatham ML, Kirkpatrick A, Sugrue M, Parr M, De Waele J, Balogh Z, Leppäniemi A, Olvera C, Ivatury R, D'Amours S, Wendon J, Hillman K, Johansson K, Kolkman K, Wilmer A. Intensive Care Med. 2006 Nov;32(11):1722-32.

Antimicrobial resistance in nosocomial bloodstream infection associated with pneumonia and the value of systematic surveillance cultures in an adult intensive care unit. Depuydt PO, Blot SI, Benoit DD, Claeys GW, Verschraegen GL, Vandewoude KH, Vogelaers DP, Decruyenaere JM, Colardyn FA. Crit Care Med. 2006 Mar;34(3):653-9.

Impact of recent intravenous chemotherapy on outcome in severe sepsis and septic shock patients with hematological malignancies. Vandijck DM, Benoit DD, Depuydt PO, Offner FC, Blot SI, Van Tilborgh AK, Nollet J, Steel E, Noens LA, Decruyenaere JM. Intensive Care Med. 2008 May;34(5):847-55. Epub 2008 Jan 24.

Patients admitted to the ICU after cardiopulmonary resuscitation; an analysis of outcome, quality of life and cost-effectiveness. Oeyen S, Vandijck D., Vandenbossche J , Benoit D, Annemans L, Colardyn F, Decruyenaere J. Value in Health, 2009, 12 (7), A329.

Outcome and early prognostic indicators in patients with a hematologic malignancy admitted to the intensive care unit for a life-threatening complication. Benoit DD, Vandewoude KH, Decruyenaere JM, Hoste EA, Colardyn FA. Crit Care Med. 2003 Jan;31(1):104-12.

Prevalence and Factors of Intensive Care Unit Conflicts, The Conflicus Study. Ely Azoulay, Jean-Francxois Timsit, Charles L. Sprung, Marcio Soares, Katerina Rusinova, Ariane Lafabrie, Ricardo Abizanda, Mia Svantesson, Francesca Rubulotta, Bara Ricou, Dominique Benoit, Daren Heyland, Gavin Joynt, Adrien Francxais, Paulo Azeivedo-Maia, Radoslaw Owczuk, Julie Benbenishty, Michael de Vita, Andreas Valentin, Akos Ksomos, Simon Cohen, Lidija Kompan, Kwok Ho, Fekri Abroug, Anne Kaarlola, Herwig Gerlach, Theodoros Kyprianou, Andrej Michalsen, Sylvie Chevret, and Benoıt Schlemmer, for the Conflicus Study Investigators and for the Ethics Section of the European Society of Intensive Care Medicine; Am J Respir Crit Care Med Vol 180. pp 853–860, 2009.

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