Thoracic Oncology

Medewerkers

Staf:

Prof. dr. Jan van Meerbeeck

Prof. dr. Kurt Tournoy 

dr. Veerle Surmont

dr. Karim Vermaelen

Doctorandi: 

Kevin Hollevoet

Bihiyga Salhi

Onderzoeksprojecten

Thoracic oncology programme: from bench to bedside

The Thoracic Oncology unit is part of the multidisciplinary oncological programme of the Ghent University Hospital. As such, a close collaboration is present with related oncological disciplines -thoracic surgery, radiotherapy and medical oncology. Besides providing tertiary care to patients with thoracic tumours - lung cancer, mesothelioma, thymoma - the unit focuses on the following aspects of clinical research:

  • molecular aspects of (differential) diagnosis and respons/relaps prediction.
  • cost-effective diagnosis and re-staging of the mediastinum with (minimally) invasive techniques, e.g. endothoracic ultrasound
  • concurrent chemoradiotherapy treatment for selected patients with stage III non-small cell lung cancer and limited stage small cell lung cancer.
  • trimodality treatment of pleural mesothelioma with induction chemotherapy, extrapleural pneumonectomy and radiotherapy.
  • validation of biomarkers in mesothelioma
  • rehabilitation in radically treated lung cancer and mesothelioma patients

The Thoracic Oncology Programme has a broad portfolio of translational, diagnostic and intervention trials, either investigator- initiated or industry- initiated, is active member of the EORTC Lung Cancer Group and promotes several pivotal multicenter phase 3 trials. The unit offers a one year fellowship in thoracic oncology to trainees, following their certification as chest physician.

Publicaties 2009

Tournoy KG, Rintoul RC, van Meerbeeck JP, Carroll NR, Praet M, Buttery RC, van Kralingen KW, Rabe KF, Annema JT. EBUS-TBNA for the diagnosis of central parenchymal lung lesions not visible at routine bronchoscopy. Lung Cancer 2009; 63 : 45–49.

Dehing-Oberije C, Yu S, De Ruysscher D, Meerschout S, van Beek K, Lievens Y, van Meerbeeck J, De Neve W, Fung G, Bharat R, Krishnan S, van der Weide H, Lambin P. Development and external validation of a prediction model for 2-year survival of non-small cell lung cancer patients treated with radiotherapy. Int J Radiat Oncol Biol Phys. 2009: doi:10.1016/j.ijrobp.2008.08.052.

Rintoul RC, Tournoy KG, Buttery RC, Carroll NR, Daly HE, van Kralingen K, van Meerbeeck JP, Rabe KF, Annema JT. EBUS-TBNA for the clarification of PET positive intra-thoracic lymph nodes. An international multi-centre experience. J Thor Oncol 2009; 4: 44-48.

Van Meerbeeck JP, Surmont VFM. Clinical stage IIIA-N2 NSCLC: a review of its treatment approach. Lung Cancer 2009; 65(3):257-67.

Hollevoet K, Bernard D, Langlois M, Walgraeve N, Van Den Eeckhout A, De Geeter F, Vanholder, R, Van de Wiele C, Stove V, Van Meerbeeck JP, De Langhe Joris. Glomerular filtration rate is a confounder for the determination of soluble mesothelin in serum. Clin Chem. 2009; 55 (7): 1431–40.

Vandenbroucke E, De Rycke F, Surmont V, van Meerbeeck JP. What is the role for surgery in patients with stage III non-small cell lung cancer? Curr Opin Pulm Med 2009; 15:295–302.

Chansky K, Sculier JP, Crowley JJ, Giroux D, Van Meerbeeck JP, Goldstraw P, on behalf of the International Staging Committee§ and Participating Institutions. The IASLC Lung Cancer Staging Project: Prognostic Factors and Pathologic TNM Stage in Surgically Managed Non-Small Cell Lung Cancer. J Thorac Oncol 2009; 4(7):792-801.

Van Meerbeeck J, Baas P. Palliative chemotherapy: Do we need yet another end-point? Eur J Cancer 2009; 45(13):2234-5 doi:10.1016/j.ejca.2009.05.020 [IF: 4.475]

Pallis AG, Serfass L, Dziadziusko R, van Meerbeeck JP, Fennell D, Lacombe D, Welch J, Gridelli C. Targeted therapies in the treatment of advanced/metastatic NSCLC. Eur J Cancer 2009; 45(14):2473-87.

Francart J, Vaes E, Henrard S, Legrand C, Baas P, Gaafar R, van Meerbeeck JP, Sylvester R, Robert A. A Prognostic index for progression free survival in malignant mesothelioma with application to the design of phase II trial: an analysis of 10 combined EORTC trials. Eur J Cancer 2009; 45(13):2304-11.

Scherpereel A, Astoul P, Baas P, Berghmans T, Clayson H, de Vuyst P, Dienemann H, Galateau-Salle F, Hennequin C, Hillerdal G, Le Péchoux C, Mutti L, Pairon JC, Stahel R, Van Houtte P, van Meerbeeck JP, Waller D, Weder W. Guidelines of the ERS/ESTS for management of Malignant Pleural Mesothelioma. Eur Resp J 2009 Published on August 28, 2009.

Demedts I, Vermaelen K, van Meerbeeck JP. Treatment of ES-SCLC: current status and future prospects. Eur Resp J 2009.

Pallis AG, Gridelli C, van Meerbeeck JP, Greillier L, Wedding U, Lacombe D, Welch J, Belani CP, Aapro M. EORTC Elderly Task Force and Lung Cancer Group and International Society for Geriatric Oncology (SIOG) experts' opinion for the treatment of non-small-cell lung cancer in an elderly population. Ann Oncol. 2009 Aug 28.

Navani N, Nankivell M, Stephens R, Parmar M, Gilligan D, Nicolson M, Groen HJM, van Meerbeeck JP. Inaccurate clinical nodal staging of non-small cell lung cancer: evidence from the MRC LU22 multi-centre randomised trial. Thorax 2009 (letter).

Tournoy KG, Annema T, Krasnik M, Herth F, van Meerbeeck JP. Endocopic Ultrasonography According to the Proposed Lymph Node Map Definition in the Forthcoming Seventh Edition of the TNM Classification for Lung Cancer. J Thor Oncol 2009.

Giroux DJ, Rami-Porta R, Chansky K, Crowley JJ, Groome PA, Postmus PE, Rusch V, Sculier JP, Shepherd FA, Sobin L, Goldstraw P; International Association for the Study of Lung Cancer International Staging Committee. The IASLC Lung Cancer Staging Project: data elements for the prospective project. J Thorac Oncol. 2009; 4(6):679-83.

Le Péchoux C, Dunant A, Senan S, Wolfson A, Quoix E, Faivre-Finn C, Ciuleanu T, Arriagada R, Jones R, Wanders R, Lerouge D, Laplanche A; Prophylactic Cranial Irradiation (PCI) Collaborative Group. Standard-dose versus higher-dose prophylactic cranial irradiation (PCI) in patients with limited-stage small-cell lung cancer in complete remission after chemotherapy and thoracic radiotherapy (PCI 99-01, EORTC 22003-08004, RTOG 0212, and IFCT 99-01): a randomised clinical trial. Lancet Oncol. 2009 May;10(5):467-74.

Rusch VW, Asamura H, Watanabe H, Giroux DJ, Rami-Porta R, Goldstraw P; Members of IASLC Staging Committee. The IASLC lung cancer staging project: a proposal for a new international lymph node map in the forthcoming seventh edition of the TNM classification for lung cancer. J Thorac Oncol. 2009;4(5):568-77.

Vallières E, Shepherd FA, Crowley J, Van Houtte P, Postmus PE, Carney D, Chansky K, Shaikh Z, Goldstraw P; International Association for the Study of Lung Cancer International Staging Committee and Participating Institutions. The IASLC Lung Cancer Staging Project: proposals regarding the relevance of TNM in the pathologic staging of small cell lung cancer in the forthcoming (seventh) edition of the TNM classification for lung cancer. J Thorac Oncol. 2009;4(9):1049-59.

Volledige publicatielijst Prof. Van Meerbeeck

Samenwerkingsverbanden

  • Lab of Mucosal Immunology: (UGent) Prof. Bart Lambrecht
  • Lab of Medical Physics: (UGent) Prof. H. Thierens
  • Lab of Human Genetics: (UGent) Prof. Nadine Van Roy
  • Lab of Pathology: (UGent) Prof. Marleen Praet
  • Clinical Chemistry Lab: (UGent) Prof. J. Delanghe
  • Department of Molecular Biotechnology: (UGent) Prof. Van Crieckinghe
  • Fund of Occupational Diseases: (Thimpont, Brussels)
  • Colleagues from the University Hospitals of Antwerp, Brussels (St Pierre, Erasme, UZB), Liège, Leuven and St Jans Hospital /Brugge, LUMC (Leiden, the Netherlands), AvL-NKI (Amsterdam, the Netherlands), MAASTRO (Maastricht, the Netherlands)
  • Lab of Medical Physics: (UGent) H. Thierens
  • Lab of Human Genetics: (UGent) Prof. Nadine Van Roy
  • Lab of Pathology: (UGent) Prof. Marleen Praet
  • Clinical Chemistry Lab: (UGent) J. Delanghe
  • Department of Molecular Biotechnology: (UGent) Van Crieckinghe
  • Fund of Occupational Diseases: (Thimpont, Brussels)
  • Colleagues from the University Hospitals of Antwerp, Brussels (St Pierre, Erasme, UZB), Liège, Leuven and St Jans Hospital /Brugge, LUMC (Leiden, the Netherlands), AvL-NKI (Amsterdam, the Netherlands), MAASTRO (Maastricht, the Netherlands)