Biochemistry I

General information

Lecturer: Prof. dr. E. Meyer; Year taught: 2nd Bachelor of Veterinary Medicine

Position of the course

The objective of this course is to acquire insight in the most important aspects of the normal cellular metabolism of domestic animals. A central theme is the relationship between the molecular structure and the biological function of biomolecules. The focus lies on the catabolism i.e. the different metabolic pathways that can deliver energy for the animal. This particular aim is linked to the general aim of the bachelor education in veterinary medicine because not only the assimilation but mostly the critical interpretation of the biomedical knowledge is stimulated. 

Contents

In this course, the focus lies on the relationship between molecular structure, biochemical function and the underlying reaction mechanisms of biomolecules. Following an overview of the class of coenzymes and an introductory chapter, the general metabolic pathways common for all domestic animals and all organs are discussed per class of biomolecules (glycolysis, Krebs cycle, pentose phosphate shunt, beta-oxidation, transamination and metabolism of nucleotide bases). In a final chapter the basic principles of signal transduction and regulation of the metabolic pathways are provided.

Final competences

The end terms comprise the knowledge and insight in the structure and metabolism of the four important classes of biomolecules. In this course the focus lies on the normal metabolic pathways which are common for all domestic animals. For the saccharide and lipid metabolism mostly the catabolic aspects are highlighted. With this knowledge, it should be possible for the bachelor student to gain insight in the strategy of energygain and -loss and in the underlying reaction mechanisms, and to understand the relationship between the different metabolic conversions and their regulation on a cellular level. Therefore, this course forms a basis for further courses like the pathobiochemistry, organ physiology and the pharmacology. These end terms are integrated within the general end terms of the bachelor education, i.e. a thorough knowledge of the structure and the function of the (biomolecules of) domestic animals in a medical context and the problem-solving orientation of this knowledge.