General Pharmacology

General information

Lecturers: Prof. dr. S. Croubels, Prof. dr. M. Devreese; Year taught: 3rd Bachelor of Veterinary Medicine

Position of the course

The student is informed about the general basic principles of action and essential mechanisms, pharmacodynamics and pharmacokinetics of veterinary drugs. More particularly the main targets of veterinary medicines in the domestic animal are overviewed. Also aspects such as drug-drug interactions are discussed.

Contents

Basic principles of veterinary pharmacology. Important issues such as pharmaceutical formulation and pharmacokinetic processes such as absorption, distribution, elimination and bioavailability are discussed. The pharmacodynamics of drugs will treat general mechanisms of action, dose-response curve, receptor theory, molecular targets, agonism / antagonism of drugs and PK-PD modelling.

Final competences

  1. Sufficient to provide the student knowledge and understanding of the basic pharmaceutics and pharmacology with emphasis on general pharmaceutics, pharmacodynamics and pharmacokinetics of veterinary drugs.
  2. To interpret drug concentration-time curves after single and multiple dosing for parenteral and oral drug administration.
  3. To use pharmacokinetic models: linear and non-linear kinetics, one- and two- compartmental models.
  4. To calculate the main pharmacokinetic parameters such as half-life, volume of  distribution, clearance, bioavailability, ...
  5. To calculate the posology of a drug using its pharmacokinetic proporties.
  6. To interpret scientific leaflets of veterinary drugs, i.c. the pharmacokinetic and pharmacodynamic properties, and posology.
  7. To gain insight in the similarities of pharmacokinetic processes between men and animals (multidisciplinarity), as well as in the use of laboratory animals as preclinical PK animal model for humans.
  8. To be aware of the economical context related to the pharmacological treatment of patients with respect to generic drugs (multiperspectivism).