Toxicology

General information 

Lecturer: Prof. dr. S. Croubels; Year taught: 1st Master of Veterinary Medicine

Position of the course

Provide students knowledge about the most common toxic agents and plants for animals, which occur in Belgium and The Netherlands. Dynamic mechanisms (pathogenesis), diagnosis, treatment options, sampling strategies and laboratory analyses to identify an intoxication are important issues.

Contents

In the general part of the course in toxicology, the basic principles of toxicology, i.e. safety and toxicity studies, toxicokinetics and biotransformation reactions, general treatment and antidotes, sampling strategies to confirm a possible intoxication, etc. are discussed. This part also includes general principles of plant biology, e.g. with respect to toxic plants and the classification of toxic agents from plant origin, etc. Next, the toxic agents are discussed in the specific part of the course, i.e. in relation to body systems and organs such as skin and mucous membranes - blood and blood coagulation - cardiovascular system - liver function - kidney function - cell metabolism - locomotory system and skeleton - central nervous system - autonomous nervous system.

Final competences

  • To know the ethiology, toxicity, toxicokinetics, pathogenesis, symptoms and lesions of intoxications of animals
  • To know the general treatment and specific treatment with antidotes of intoxications in animals
  • To understand a correct sampling strategy and analysis of samples to confirm a toxicological diagnosis
  • To interpret chemical-analytical test results related to a toxicological diagnosis
  • To recognise toxic plants and to know the toxic agents from plant origin- To search scientific information, such as case reports of intoxications, and to be able to synthetize and analyze these data