Services

Laboratory of Pharmacology and Toxicology

Questions regarding pharmacological problems as well as toxicological analyses should be directed to or at +32 (0)9 264 73 50.

Toxicology

Following forms can be used to request a toxicological analysis:

We provide qualitative and quantitative detection of several poisonous substances using HPLC-MS/MS or HPLC-UV detection:

  • Carbamates and phosphate esters, e.g. aldicarb, carbofuran, parathion
  • Coumarines, e.g. coumarine, warfarine, chlorophacinone
  • Organochlorated compounds, e.g. lindane
  • Heavy metals and metalloids, e.g. copper, lead, arsenic, thallium
  • Others: alfa-chloralose, methaldehyde, strychnine, taxus, T-61

Pharmacology

The laboratory is GLP compliant since 2001 for pharmacokinetic and residue studies. 

Contract service work includes inter alia

  • Safety and residue studies
  • Bioavailability studies and pharmacokinetic analysis (compartmental and noncompartmental modeling) with emphasis on absorption, distribution, metabolisation and excretion (ADME) of veterinary drugs and toxic agents
  • Residue depletion and withdrawal time calculation according to EMA guidelines (tissues EMEA/CVMP/035/95, milk EMEA/CVMP/473/98)
  • Development of HPLC-UV, HPLC-fluorescence and LC-MSn methodology for quantifications of drugs and toxins in biological matrices
  • Efficacy testing of mycotoxin binders using a toxicokinetic approach in pigs and broiler chickens

Laboratory of Biochemistry

We offer scientific services based on our thorough expertise with the following techniques, described in standard operating procedures (SOP) and according to good scientific practices (GSP):

  • Mouse mammary gland intraductal injection model to study bovine mastitis and breast cancer (i.e. screening of candidate therapeutics)
  • ELISA of urinary biomarkers for acute kidney injury in different species (other parameters on request)
  • Multiplex analysis of secreted proteins on serum, plasma, tissue lysates in the context of inflammation and cell death in different species
  • Flow cytometric analysis e.g. immunophenotyping, cell death, bacterial and fungal viability, ROS production, genome size, ... on a state-of-the-art 3 laser flow cytometer

For further information contact or