Lecture 'Z-RNA: a novel antiviral PAMP?'

For whom
Students, Employees, Alumni, Business
When
20-10-2017 from 11:30 to 12:45
Where
UGent-VIB-onderzoeksgebouw, Technologiepark 927, 9052 Zwijnaarde
Language
English
Organizer
VIB-UGent Center for Inflammation Research (GE01/WE14/WE10)
Contact
coordination@irc.vib-ugent.be
Website
http://www.irc.ugent.be/index.php?id=seminars
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Jonathan Maelfait from VIB-UGent Center for Inflammation Research will explain how cells sense viral RNA and commit suicide by necroptosis

The detection of viruses by the innate immune system depends on antiviral pattern recognition receptors. These receptors monitor different cellular compartments for the presence of nucleic acids indicative of viral infection. Importantly, the host must be able to discriminate between RNA and DNA molecules that reside inside healthy cells and those that accumulate during viral infection. I will discuss how sensing of viral invasion by the antiviral receptor Z-DNA binding protein-1 (ZBP1 or DAI) relies on detecting RNA in the zig-zagged shape - in short, Z-RNA - and how this clears infection by triggering cellular suicide under the form of necroptosis.