Lecture 'Metabolic Regulation of ILC Mediated Barrier Protection and Pathology'

For whom
Students, Employees, Alumni, Business
12-01-2018 from 11:30 to 12:45
UGent-VIB-onderzoeksgebouw, Technologiepark 927, 9052 Zwijnaarde
VIB-UGent Center for Inflammation Research (GE01/WE14/WE10)
Add to my calendar

Dr. Christoph Wilhelm will tell us more on innate lymphoid cells and the role of metabolism in these cells.

Dr. Christoph Wilhelm (Institute of Clinical Chemistry and Clinical Pharmacology, University Hospital Bonn, University of Bonn, Germany) will present his work on innate lymphoid cells.
Innate lymphoid cells (ILC) are a group of immune cells, which control immunity, inflammation and homeostasis in tissues like the lung, gut and the skin. While the primary function of ILC is the guarding of the tissue barrier, chronic activation may result in chronic inflammation. Recently, we could show that type 2 innate lymphoid cells (ILC2) rely on fatty acid oxidation (FAO) during helminth infection to maintain their protective function. However, whether both protective and pathogenic ILC responses underlie a similar metabolic control is completely unknown. To address this question we are currently dissecting the metabolic control of type 2 innate lymphoid cells (ILC2) with the aim to reveal metabolic programs dictating protection or immune pathology.