Lecture 'How IL-17 contribute to CNS inflammation'

For whom
Students, Employees, Alumni, Business
When
02-02-2018 from 11:30 to 12:45
Where
UGent-VIB-onderzoeksgebouw, Technologiepark 927, 9052 Zwijnaarde
Language
English
Organizer
VIB-UGent Center for Inflammation Research (GE01/WE14/WE10)
Contact
coordination@irc.vib-ugent.be
Website
http://www.irc.ugent.be/index.php?id=seminars
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The role of interleukin-17 on the microbiome of the gut and how this influences the development of multiple sclerosis in mice will be discussed.

Ari Waisman from the Institute for Molecular Medicine of Mainz, University of Mainz will present his work today.

More information on his talk: We found that mice lacking interleukin-17A (IL-17A) and IL-17F are resistant to the development of experimental autoimmune encephalomyelitis (EAE), which is the mouse model for multiple sclerosis. In the talk, I will discuss how IL-17 affects the microbial population in the gut of the mice and how that translates to resistance or susceptibility to EAE. Furthermore, I will discuss the tissue-specific effect of IL-17 mediated signalling in specific cells of the central nervous system (CNS), such as blood brain barrier endothelial cells.