Lecture 'The choroid plexus epithelium: a small brain barrier with big therapeutic potential'

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Students, Employees, Alumni, Business
09-02-2018 from 11:30 to 12:45
UGent-VIB-onderzoeksgebouw, Technologiepark 927, 9052 Zwijnaarde
VIB-UGent Center for Inflammation Research (GE01/WE14/WE10)
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Roosmarijn Vandenbroucke (VIB-UGent Center for Inflammation Research) will tell us more about her work on the choroid plexus epithelium of the brain.

Although largely understudied, the choroid plexus epithelium (CPE), forming the blood-cerebrospinal fluid (CSF) barrier, is an important and unique single layer of epithelial cells situated at the interface between blood and CSF. Subtle changes in the CPE, via changes in the CSF composition, have wideranging effects on the brain and will subsequently affect disease progression. Therefore, understanding blood-CSF barrier functionality under physiological and pathophysiological conditions might open up new therapeutic strategies to treat inflammatory diseases. Our research focuses on the effect of systemic inflammation, e.g. sepsis, and neuroinflammation, e.g. Alzheimer's disease, on the blood-CSF barrier. We study which key molecules play a role in activated detrimental processes at the blood-CSF barrier upon inflammation, focusing on barrier integrity and extracellular vesicle (exosome) secretion and we analyze whether targeting this detrimental processes has therapeutic potential.