Lecture 'Lin28b potentiates positive selection of immature B cells early in life'

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Students, Employees, Alumni, Business
15-06-2018 from 11:30 to 12:45
UGent-VIB-onderzoeksgebouw, Technologiepark 927, 9052 Zwijnaarde
VIB-UGent Center for Inflammation Research (GE01/WE14/WE10)
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Stijn Vanhee (Division of Molecular Hematology, Lund University) will explain his work on B cell development in neonatal life.

The adult adaptive immune system is comprised of a wide spectrum of lymphocyte subsets with distinct antigen receptor repertoire profiles, effector functions, turnover times and anatomical locations, acting in concert to provide optimal host protection and self-regulation. This is clearly exemplified in the B cell lineage where long-lived neonatal derived CD5+ B-1 (B-1a) cells expressing a self-reactive repertoire exhibit non-redundant immune and homeostatic functions.
To date, it has remained enigmatic as to how such self-reactive B cells are allowed to be generated during early life lymphopoiesis and why their output declines during neonatal life.
Our data support a model in which developmentally restricted expression of the heterochronic RNA binding protein Lin28b potentiates a transient wave of B cell positive selection during neonatal life and thereby contributes to life-long heterogeneity within the B cell pool.