Lecture 'Regulation of chronic intestinal pathology by autophagy'

For whom
Students, Employees, Alumni, Business
When
21-06-2018 from 09:30 to 10:45
Where
UGent-VIB-onderzoeksgebouw, Technologiepark 927, 9052 Zwijnaarde
Language
English
Organizer
VIB-UGent Center for Inflammation Research (GE01/WE14/WE10)
Contact
coordination@irc.vib-ugent.be
Website
http://www.irc.ugent.be/index.php?id=seminars
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Kevin Maloy will explain how autophagy acts in cell-type, tissue-specific and context-dependent ways to regulate intestinal inflammation.

Kevin Maloy (Sir William Dunn School of Pathology, University of Oxford, UK) is our guest speaker. More information on his talk:

Although polymorphisms in autophagy genes are associated with risk of inflammatory bowel disease, the precise cellular and molecular mechanisms through which autophagy regulates intestinal immune homeostasis are not well understood.

By using a conditional knockout approach, we found that selective deletion of the autophagy gene Atg16l1 in T cells led to spontaneous inflammation in the small intestine that was characterised by a loss of intestinal Treg cells and by an outgrowth of Th2 cells. We could further show that autophagy protects intestinal epithelial cells from inflammatory cytokine induced apoptosis and that blockade of TNF alleviated the susceptibility phenotype.

Together, these studies show that autophagy acts in cell-type, tissue-specific and context-dependent ways to regulate intestinal inflammation.