Lecture 'Control of metabolic homeostasis at the single-cell level'

For whom
Students, Employees, Alumni, Business
When
14-11-2018 from 15:00 to 16:00
Where
UGent-VIB-onderzoeksgebouw, Technologiepark 927, 9052 Zwijnaarde
Language
English
Organizer
VIB-UGent Center for Inflammation Research (GE01/WE14/WE10)
Contact
ruth.vanlaere@ugent.be
Website
http://www.irc.ugent.be
Add to my calendar

Prof. John Albeck, University of California, Davis, CA, US

An essential feature of metabolic regulation is the ability to adjust metabolite flux to support functions including cell growth and division. To understand how this homeostatic process functions at the level of a single cell, we have combined live-cell reporters for AMPK, a central energy-sensing kinase, and for key metabolites including ATP and NADH. In response to metabolic stresses, this approach reveals cellular heterogeneity in metabolic state and interlocked oscillations in signaling and metabolic parameters. Our results highlight the importance of continuous, dynamic feedback regulation in balancing anabolic and catabolic processes within the cell.