Lecture 'A bitter sweet symphony: how tumor-associated glycans orchestrate immune evasion'

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Students, Employees, Alumni, Business
14-12-2018 from 11:30 to 12:45
UGent-VIB-onderzoeksgebouw, Technologiepark 927, 9052 Zwijnaarde
VIB-UGent Center for Inflammation Research (GE01/WE14/WE10)
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Dr. Sandra van Vliet will tells us more on glycosylation in tumor immunity. Registration for the seminar is not needed.

Dr. Sandra van Vliet (Amsterdam UMC, VU University Medical Center, Amsterdam, The Netherlands) is our guest speaker.

Glycans play a crucial role in shaping adaptive immune responses. The recognition of glycans by glycan-binding receptors, such as the Siglecs and C-type lectins, has illustrated their potent immune modulatory role and has implicated glycans not only in infectious diseases, but also revealed their extraordinary properties in tumor progression.

We study how the “sugar blue print” is decoded by the immune system and how aberrant glycans orchestrate immune evasion during cancer. Our results imply a direct effect of aberrant glycosylation on anti-tumor immunity, in both a carbohydrate-specific as well as tumor type-specific manner, confirming that tumor glycans should be considered as a powerful immune evasion strategy.