Lecture 'Adipose inflammation and metabolic health'

For whom
Students, Employees, Alumni, Business
29-03-2019 from 11:30 to 12:45
UGent-VIB-onderzoeksgebouw, Technologiepark 927, 9052 Zwijnaarde
VIB-UGent Center for Inflammation Research (GE01/WE14/WE10)
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Prof. Alexander Bartelt, Institute for cardiovascular Prevention, Ludwig-Maximilians-University, Munich (DE) adipocytes inflammation metabolism

Adipocytes are essential for metabolic homeostasis but obesity-related adipose tissue dysfunction is a key component of insulin resistance, diabetes and cardiovascular complications. In this presentation I am going to highlight what defines white, brown and beige adipocytes and how these cells maintain metabolic health in fasting and cold exposure, facilitate weight loss and protect from atherosclerosis. Even though adipocytes are the primary storage organ of excess nutrients, in obesity this capacity is challenged and through a variety of mechanisms, resulting in adipocyte dysfunction, cellular stress and adipose inflammation. I am going to discuss novel mechanisms of adipocyte adaptation for thermogenesis and suppression of inflammation based on our recent work on adipocyte endoplasmic reticulum stress and proteostasis.