Lecture 'Inflammatory responses to Cell Stress by Seamus J. Martin'

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Students, Employees, Alumni, Business
16-05-2019 from 14:00 to 15:30
UGent-VIB-onderzoeksgebouw, Technologiepark 71, 9052 Zwijnaarde
VIB-UGent Center for Inflammation Research (WE14, WE10, GE35)
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Seamus J. Martin (The Smurfit Institute, Trinity College, The University of Dublin) will show his work on cell stress-associated inflammation.

Although inflammatory responses are primarily beneficial in terms of their wound healing properties and by initiating immune responses towards infectious agents, a slow buildup of inflammation is frequently seen in multiple human diseases that does not appear to be either PAMP- or DAMP-driven. The latter type of inflammation is a major compounding factor in multiple conditions such as obesity, stroke, type II diabetes, neurodegenerative disease and solid cancers, which can escalate disease progression. Thus, understanding how stress-induced inflammation is initiated has major implications for multiple diseases. However, although we now know a great deal about how infection and tissue necrosis promote inflammation, how inflammation is initiated in response to cell stress is obscure by comparison. Here, I will discuss recent data from our laboratory which suggest that cell stress-associated inflammation is routed via death receptors.
Registration for the seminar is not required.