Lecture 'Regulation of Met1-linked ubiquitin signalling by OTULIN in inflammation and disease'

For whom
Students, Employees, Alumni, Business
When
21-06-2019 from 11:30 to 12:45
Where
UGent-VIB-onderzoeksgebouw, Technologiepark 71, 9052 Zwijnaarde
Language
English
Organizer
VIB-UGent Center for Inflammation Research (WE14, WE10, GE35)
Contact
coordination@irc.vib-ugent.be
Website
https://www.irc.ugent.be/index.php?id=tocalendar
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Dr. Rune Busk Damgaard (MRC Laboratory of Molecular Biology, Cambridge Biomedical Campus, UK) will tell us more on the role of OTULIN in inflammation.

Inflammation is a protective response to infection or tissue damage. However, persistent or dysregulated inflammation can be harmful and cause severe immune disease. Met1-linked ubiquitin chains are important regulatory posttranslational modifications in NF-kB signalling, inflammation, and cell death.

We recently discovered the human immune disease OTULIN-Related Autoinflammatory Syndrome (ORAS) caused by mutations in Met1-linked ubiquitin-specific deubiquitinase OTULIN.

We are investigating the cellular and molecular mechanisms whereby OTULIN regulates Met1-linked ubiquitin signalling and how dysregulation of Met1-linked ubiquitin signalling affects inflammation and contributes to disease.