Lecture 'Characterization and targeting of B.anthracis’ armor: the new way to fight Anthrax'

For whom
Students, Employees, Alumni, Business
When
04-10-2019 from 11:30 to 12:45
Where
UGent-VIB-onderzoeksgebouw, Technologiepark 71, 9052 Zwijnaarde
Language
English
Organizer
VIB-UGent Center for Inflammation Research (WE14, WE10, GE35)
Contact
coordination@irc.vib-ugent.be
Website
https://www.irc.ugent.be/index.php?id=tocalendar
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A novel way to fight anthrax by using nanobodies that target the surface protein layer of B. anthracis.

Anthrax is an ancient and deadly disease caused by the spore-forming bacterial pathogen Bacillus anthracis. The cell surface of B. anthracis is covered by a protective paracrystalline monolayer—known as surface layer or S-layer—that is composed of the S-layer proteins Sap or EA1.

Dr. Antonella Fioravanti (VIB-VUB Center for Structural Biology, Brussels) generated nanobodies to inhibit the self-assembly of Sap, and determined the structure of the Sap S-layer assembly domain. Remarkably, Sap-inhibitory nanobodies can disintegrate the S-layer, attenuate the growth of B. anthracis and protect mice from lethal infection.

Dr. Fioravanti presents disruption of S-layer integrity as a mechanism that has therapeutic potential in S-layer-carrying pathogens.