Lecture 'The cross-talk between neurons and resident macrophages in the gut'

For whom
Students, Employees, Alumni, Press
18-10-2019 from 11:30 to 12:45
UGent-VIB-onderzoeksgebouw, Technologiepark 71, 9052 Zwijnaarde
VIB-UGent Center for Inflammation Research (WE14, WE10, WE02, GE35)
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In this talk you will gain insight in the crosstalk of macrophages with neurons in the gut and its relevance for gut disorders.

Professor Guy Boeckxstaens (Translational Research Center for GI Disorders, University Hospital Leuven) is our guest speaker.

The enteric nervous system, also referred to as the “Little brain of the gut” is surrounded by a network of long-lived self-renewing macrophages. To date, it is becoming increasingly clear that these macrophages closely interact with enteric neurons in a bidirectional fashion. Neurons most likely imprint the “microglia-like” transcriptomic profile of these neuron-associated macrophages and are able to suppress their activation. Conversely, neuron-associated macrophages contribute to the pruning of synapses and the optimization of the neural circuitry in early life, and are key players in the nourishment and maintenance of enteric neurons in adulthood.

Insight in the crosstalk between enteric neurons and neuron-associated macrophages will be of great relevance for the treatment of immune-mediated and neurodegenerative disorders of the gut.