Lecture 'Unravelling antigen presentation  pathways in autoimmunity: the type 1 diabetes example'

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Students, Employees, Alumni, Business
24-01-2020 from 11:30 to 12:45
UGent-VIB-onderzoeksgebouw, Technologiepark 71, 9052 Zwijnaarde
VIB-UGent Center for Inflammation Research (WE14, WE10, WE02, GE35)
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Emil R. Unanue (Washington University School of Medicine) explains the immunological interactions within the pancreatic islets in health and disease.

We examine pancreatic islets in order to understand how a tissue conveys its immunological information to the immune system. Islets, the targets of diabetic autoimmunity, are mini-organs of about 1000 endocrine cells, mostly the insulin producing beta cells- and one set of resident myeloid cells. The resident myeloid cell is a macrophage in a highly activated state, independent of the autoimmune status. We will review the biology of such macrophages and their dual role, in maintaining homeostasis in islets, and in the initiation of autoimmunity. We will detail the interactions taking place in islets among beta cell, macrophages and the CD4 T cells that initiate the process and explain the nature of the autoantigens. Our studies in NOD mice have identified critical peptides from insulin molecule that trigger a set of unconventional autoreactive T cells.