Lecture 'Detecting Death and Damage; Understanding Macrophage migration in vivo'

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Students, Employees, Alumni, Business
25-02-2020 from 11:30 to 12:45
UGent-VIB-onderzoeksgebouw, Technologiepark 71, 9052 Zwijnaarde
VIB-UGent Center for Inflammation Research (WE14, WE10, WE02, GE35)
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Will Wood (University of Edinburgh) will explain how wounding triggers immune cell migration and how cells react to competing cues in the process.

A critical early wound response is the recruitment of inflammatory cells drawn by danger cues released by the damaged tissue. Hydrogen peroxide has been identified as the earliest wound attractant in Drosophila and Zebrafish and we have shown using fly embryos that laser wounding activates the NADPH oxidase DUOX to generate hydrogen peroxide. As a consequence of hydrogen peroxide production, macrophages within the fly embryo rapidly migrate toward the wound site powered by the formation of dynamic actin-rich lamellipodia. We use live imaging to understand the mechanism by which inflammatory cells are able to detect H2O2 and generate the dynamic actin-rich structures necessary for their migration. We are particularly interested in how immune cells are able to prioritise competing cues such as wound induced damage signals and ‘eat me’ cues from apoptotic corpses and how exposure to one of these signals influences the cells ability to respond to subsequent cues.