Lecture 'Metabolic control of dendritic cell-driven T cell priming and polarization'

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Students, Employees, Alumni, Business
23-10-2020 from 11:30 to 12:45
UGent-VIB-onderzoeksgebouw, Technologiepark 71, 9052 Zwijnaarde
VIB-UGent Center for Inflammation Research (GE01/WE14/WE10)
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By Dr. Bart Everts, Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands

DC’s play a crucial role in regulation of adaptive immunity by controlling priming and polarization of T cell responses. It has become clear that metabolic rewiring is fundamental to immune cell function including that of DCs. Central regulators of cellular metabolism are the nutrient sensor AMP-activated Kinase (AMPK) and its upstream activator Liver Kinase B1 (LKB1). Yet their role in DCs biology and function are only starting to be revealed. Our research suggests a key, but complex role for this AMPK signaling axis in regulating DC metabolism and T cell priming. We found the role for LKB1 to be distinct from AMPK; whereas LKB1 in DCs appears to be crucial for regulating central tolerance and Th17 responses, we found AMPK to be essential for DC-dependent control of peripheral regulatory T cell responses. These insights provide new mechanistic insight into metabolic pathways that control T cell priming by DCs and offer potential new therapeutic targets.