Lecture 'Macrophages in the uterus: a specialised type 2 environment?'

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Alumni , Business , Employees , Students
11-06-2021 from 01:30 to 02:30
VIB-UGent Center for Inflammation Research
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Elizabeth Mann (The University of Manchester, UK) will focus on the specialised role of macrophages in the uterus in mice and women.

Proliferation, differentiation and shedding of the endometrium (uterus lining) in health require precise coordination of tissue degradation, clearance of debris and tissue remodelling. In other tissues, the innate immune system is central to tissue remodelling and repair with macrophages in particular phagocytosing cellular debris and acting as regulators and effectors of the complex pro- and anti-inflammatory responses that determine tissue integrity.

However, there is a lack of fundamental understanding regarding the role of the immune system in the female reproductive tract and how it regulates tissue integrity and disease, which has led to limited treatment options for reproductive disease. I will focus on the specialised properties and functions of macrophages in the uterus, combining murine data with characterisation of macrophages from human endometrial biopsies.

To join us at the seminar: https://zoom.us/j/99579722115?pwd=ZWVsSXU3M25HcThVV3ZETjdPc3pKZz09