PhD Student

Last application date
Jul 21, 2020 22:48
Department
GE32 - Department of Diagnostic Sciences
Employment category
Doctoral fellow
Contract
Limited duration
Degree
Master degree in life sciences, pharmacy, bio-engineering
Occupancy rate
100%
Vacancy Type
Research staff

Job description

Viral infections in humans are in general kept in check by both innate and adaptive immunity. Many well-known pathogenic viruses encode proteins or small RNAs that counteract pattern recognition receptors (PRR, e.g. RIG-I) or mediators (e.g. PKR) of innate immunity, pointing to the importance of this first line defense. Stimulation of expression of anti-viral effectors is achieved by type I interferons (IFN-I), triggering receptors on both infected and uninfected cells to hamper progression of replication or protect against viral infection, respectively. For HIV, PRRs are mainly defined in myeloid cells to be either membrane bound Toll-like receptors (RNA binding receptors TLR3 and TLR7) or cytoplasmic DNA sensors such as cGAS and IFI16. We could demonstrate that HIV infection is sensed in activated CD4+ T cells (Vermeire et al., Cell Reports, 2016). Sensing of viral infection, both HIV and herpes viruses, in these primary cells will be the focus of this project. We use knock-down by lentiviral vectors encoding shRNA and trace the signal transduction pathway in virally infected cells.

Profile of the candidate

The PhD student will work independently in a team of researchers. Flexibility and creativity, next to social talents are needed to succeed in the endeavor. The suitable candidate will start on a grant and have the profile and drive to acquire additional funding for a personal scholarship. The aim is to finalize a PhD dissertation within a period of 4 to 5 years.

How to apply

Send your curriculum vitae including study scores and motivation letter to by July 21th 2020 the latest.