PhD student

Last application date
Mar 31, 2018 17:38
Limited duration
Master’s degree in biochemistry, biotechnology, (bio)medical sciences, bioengineering or equivalent.
Occupancy rate
Vacancy Type
Research staff

Job description

The research group of Prof. Tom Taghon, located in Ghent, Belgium, is looking for a talented and highly motivated PhD student to join our team. Research in our lab is focused on the functional characterization of the molecular mechanisms that control the early stages of T cell development in human in health and disease (Van de Walle et al., Journal of Experimental Medicine 2013; Van de Walle et al., Nature Communications 2016). Using human primary hematopoietic stem cells and thymocytes, successful candidates will apply state-of-the-art molecular and cell culture approaches to study the role of a particular transcription factor, GATA3 (Taghon et al., Nat. Immunology 2007); Van de Walle et al., Nature Communications 2016), in the development of normal and leukemic T cell development. Techniques include RNAseq, ChIPseq, ATACseq, in vitro cell cultures for hematopoietic stem cell differentiation (Dolens and Taghon, Nature Methods 2017) and retro- and lentiviral perturbation experiments for gain- and loss-of-function studies, also at the single cell level. In addition, a novel mouse model was recently generated to support our human studies with a genetic in vivo model. You will work together with an international group of postdocs, PhD students and technicians in a new research building on the Ghent University Hospital campus that houses leading research groups in the field of Immunology and Genetics, thereby providing a state-of-the-art and stimulating research environment.

Profile of the candidate

  •  You have strong enthusiasm for fundamental scientific research with an interest in the molecular genetics of normal and leukemic blood cell development.
  •  You are a highly motivated and flexible team player with the capacity to work independently.
  •  You have strong research and presentation skills, illustrated by your master thesis.
  • -Candidates should have a relevant master degree in biotechnology, biochemistry, (bio)medical sciences, bio-engineer, or equivalent.

How to apply

For further information or to apply (include motivation letter, curriculum vitae with study results and contact information of two potential referees), please contact : Prof. Dr. Tom Taghon (E-mail: )