Postdoctoral position in Host-Microbe Interactions and Intestinal Cancer

Last application date
Apr 30, 2018 23:55
Department
GE01 - Department of Internal medicine
Contract
Limited duration
Degree
PhD degree in biomedical sciences, medicine or molecular biology or biotechnology or should obtain a PhD in the near future
Occupancy rate
100%
Vacancy Type
Research staff

Job description

The laboratory of Intestinal Host-Microbe Communication, headed by Prof. Andy Wullaert (https://ggig.be/lab_andywullaert.php) and affiliated to Ghent University as well as the VIB Center for Inflammation Research (https://www.irc.ugent.be/index.php?id=mlapeople), offers a dynamic working environment within a stimulating scientific surrounding. You will be part of an international, young, enthusiastic, motivated team using English as the main language.

Our laboratory performs in vivo research using mouse models as well as ex vivo research using primary cells in order to fundamentally understand the relationship between the host and the inhabitants of the intestinal lumen in homeostasis and during inflammatory responses, as well as upon viral, bacterial or parasitic infectious encounters. For this purpose we have a rather large collection of mouse models available carrying genetic deficiencies (full-body and cell type specific) or missense mutations in inflammatory signaling pathways. These include TLR-, NLR- and RLR-initiated signaling pathways as well as important cellular processes such as inflammasome activation, autophagy, ubiquitination and various cell death modes. We also have mouse models for Inflammatory Bowel Disease, colorectal cancer, Auto-Inflammatory Diseases (CAPS, FMF, …), as well as gastro-intestinal viral, bacterial and parasitic infections running in the lab. The specific project for this position deals with the impact of anti-viral signaling pathways in the development of intestinal cancer in mice. The project will aim to characterize the function and the therapeutic potential of particular anti-viral responses in the development of chemical-induced as well as genetic mouse models of intestinal carcinogenesis.

Our team is embedded in the VIB Center for Inflammation Research, a multidisciplinary research center focusing on the molecular mechanisms of inflammation in allergy, autoimmune diseases, infectious diseases and cancer (http://www.irc.ugent.be/index.php?id=aboutirc), and that hosts excellent transgenic, bio-imaging and flow cytometry core facilities; as well as an SPF and a germ-free animal facility. Our team is also part of the Ghent Gut Inflammation Group (https://ggig.be/index.php), a Ghent University consortium bringing together multiple research groups investigating the various aspects of gastrointestinal physiology. The embedding of our team in the IRC and the GGIG ensures an environment enabling smooth interdisciplinary collaborations.

We offer:

  • A 4 year period postdoctoral position with a competitive salary
  • The candidate will have access to state-of-the-art tools and facilities, a rich training environment and the possibility to collaborate with many other groups within an excellence-based research institute (http://www.vib.be/en/research/Pages/default.aspx)
  • The candidate will be embedded in a competitive international research group of about 10 highly motivated (and very nice) people that work together as a team.
  • The lab is situated in Ghent, a lively city at the heart of Europe (https://visit.gent.be/en/HOME). - Starting date: as soon as possible, but flexible.

Profile of the candidate

  • The candidate must hold a PhD, or should be expecting to obtain a PhD in the near future.
  • The candidate should have experience in the areas of Host-Microbe Interactions and Mucosal Immunology in the intestinal tract.
  • The candidate must hold a Felasa C diploma (or equivalent) allowing him/her to work with laboratory animals.
  • The required skills include: working with murine cancer models, intestinal organoid cell culture, immunohistochemistry, molecular and cell biological techniques in vitro and in vivo. - Experience in omics techniques and bioinformatics would be a plus.
  • Candidates must be proficient in oral and written English, have excellent communication and multi-tasking skills, be team-oriented, proactive and results-driven.
  • Candidates are encouraged to apply for competitive fellowships during their stay in the lab.

How to apply

Please send your CV, containing a list of publications, a summary of past research, contact information of 2 or 3 referees, and a motivation letter to Prof. Andy Wullaert ()