Predoctoral researcher

Last application date
Nov 30, 2019 23:59
GE31 - Department of Biomolecular Medicine
Employment category
Research staff group 3
Unlimited duration with clause
Master of biomedical sciences, biochemistry, pharmaceutical sciences, veterinary sciences, bioscience engineering or medicine
Occupancy rate
Vacancy Type
Research staff

Job description

The translational nuclear receptor research (TNNR) team is looking for a highly motivated PhD student for a project focusing on non-alcoholic fatty liver disease (NAFLD). Worldwide, 24% of the adult population suffers from NAFLD and the prevalence is rapidly increasing in the Western world. To date, dietary and lifestyle interventions are the only treatment option underscoring the need for therapeutic targets for advanced NAFLD (NASH). Within this project, you will be involved in a detailed characterization of a novel discovered interaction between two nuclear receptors functioning at the core of hepatic energy metabolism. Further insights in this interaction may give rise to the rational design of a therapeutic strategy for the progressive form of NAFLD, called NASH. This study will involve mouse models, human primary hepatocytes and patient samples. Techniques used will include animal handling, immunohistochemistry, metabolomics, RNA-sequencing, proteomics, Western blotting, qPCR and ChIP(seq).

We offer a position for 1 year with the possibility of extension for 4 years in case of a positive FWO/BOF application. The candidate will have to apply for an FWO PhD-fellowship in February 2020. He/she will work in a stimulating multicultural environment and gain expertise in two high-quality laboratories, more precisely the molecular mechanism-oriented lab from Prof. Dr. Karolien De Bosscher and the in vivo-oriented labs from Prof. Dr. med. Anja Geerts and Prof. Dr. Lindsey Devisscher. In addition, he/she will have access to cutting-edge technologies, personal career assistance and high level training courses. The position is immediately available.

Profile of the candidate

The candidate should have a strong interest in metabolic diseases, good communication and writing skills (English), and should be able to work independently, as well as function as part of a team. As the project will include animal models, a FELASA diploma or the willingness to obtain a FELASA is required.

How to apply

Candidates should send a CV, transcript of study records, copy of the diploma (if applicable) and motivation letter along with reference letters and names/contact details of the references, both to Prof. Dr. Karolien De Bosscher ( and Prof. Dr. L. Devisscher ( The deadline for application is November 30, 2019.