Yohannes Sileshi

Sileshi YohannesContact info

Sileshi Yohannes

Drug Quality and Registration (DruQuaR) group
Ottergemsesteenweg 460, 9000 Ghent (Belgium)

Phone: + 32 (0)9 264.81.01
E-mail: SileshiBelew.Yohannes@UGent.be







Ph.D. research



Neglected tropical diseases (NTDs) currently still account for 12% of the global health burden. Although medicines are available, their generally poor quality contributes to lowered efficacy and increased toxicity and resistance. An appropriate dissolution profile of the active pharmaceutical ingredient (API) from its formulation is one of the quality attributes which considerably influences the therapeutic outcomes. In this project, the anti-malaria fixed medicine combination ß-artemether and lumefrantrine and two anthelminthics, albendazole and praziquantel, will be investigated to obtain in vivo relevant dissolution systems. Chemistry and hydrodynamics of the in vivo systems, as well as Caco-2 and helminthic permeability will be experimentally studied and IVIVR-modelled.


Keywords: Bio-relevant dissolution, Anthelminthics, Anti-malaria