Lieselotte Veryser

Lieselotte Veryser Contact info

Lieselotte Veryser

Drug Quality and Registration (DruQuaR) group
Ottergemsesteenweg 460, 9000 Ghent (Belgium)

Phone: + 32 (0)9 264.81.01 (secr. 81.01)
Fax: + 32 (0)9 264.81.93
E-mail: Lieselotte.Veryser@UGent.be

 

 

Ph.D. research

 

Title: Analytical immune functionality of N-alkylamides using brain and skin barrier models.

Summary:

Bioactive N-alkylamides (N-AAs), with spilanthol as model compound, are a promising group of bio-functional peptide compounds which are found in plants. Activities already described encompass analgesic, antimicrobial, insecticidal, sensory, anti-inflammatory and immuno-modulatory effects. As the skin has a well-developed immune system, the effect of N-AAs on the immune-functionality is not only dermatologically interesting, but can also serve as a general model to study the immune effects of N-AAs, including their analytical characterization, the quantitative structure-property/activity relationships and their specific mode of action in a spatial and temporal way. Moreover, once the N-AAs have migrated through the skin, they reach the systemic circulation, where the brain interaction through the blood brain barrier will be studied.

Keywords: N-alkylamide, spilanthol (affinin), immune functionality, skin and brain barrier

Publications