Mathieu Verbeken

Mathieu Verbeken Contact info

Mathieu Verbeken

Drug Quality and Registration (DruQuaR) group
Ottergemsesteenweg 460, 9000 Ghent (Belgium)

Phone: + 32 (0)9 264.80.94 (secr. 81.01)
Fax: + 32 (0)9 264.81.93
E-mail: Mathieu.verbeken@UGent.be

 

 

Ph.D. research


Title: Functional quality of new peptides originating from the mouse peptidome.

Summary:

The biomedical effects of new peptide pharmaceuticals, not only lead drug structures but their derived fragments, label-modified analogues, metabolites, related synthesis and degradation impurities for qualification evaluation as well, are an important aspect in drug development.  Screening systems are to be established, including receptor-ligand-binding (RLB) and tissue-bath (TB) methods.  The importance of such a biomedical, functional quality, screening approach is substantiated by the wide variety of physiological effects already seen with known peptides.  However, errors of type I (false positives or α) and type II (false negatives or β) need to be minimized and controlled.

Multivariate experimental design (DOE) are evaluated as a strategy to efficienthy, optimise and model the methods, as well as to gain more mechanistic knowledge.

Keywords: Screening, organ-bath assays, peptide drugs, receptor-ligand binding, quality

Publications