Apr. Elisabeth Slachmuylders

elisabeth

Apr. Elisabeth (Lisa) Slachmuylders

Laboratory of Pharmaceutical Microbiology (LPM)
Universiteit Gent
Ottergemsesteenweg 460
B-9000 Gent - Belgium

Tel: 32 - (0) 9 264 80 93
Fax: 32 - (0) 9 264 81 95

E-mail: Elisabeth.Slachmuylders@ugent.be

list of publications

 

Lisa Slachmuylders graduated in Pharmaceutical Sciences at Ghent University in 2013. She is currently working as a PhD student in the Laboratory of Pharmaceutical Sciences (LPM).

While an increase in antimicrobial resistance occurred over the last 20 years, a decline in antibacterial drug development has been observed. Therefore an alternative approach for antimicrobial chemotherapy was investigated, namely targeting the bacterial communication system, also known as quorum sensing (QS).

Since QS is involved in the coordination of virulence and biofilm formation and/or maturation, QS systems are considered as a target for development of novel antimicrobial agents.

Previous research in the LPM showed that QSI can weaken the bacterial biofilm and thereby increase the susceptibility of these biofilms towards antibiotics. However, the exact mechanism by which these QSI exert these effects have not ben elucidated yet.

The aim of this research is to discover this mechanism of action.