Zengyuan Wang

BIOMATH, Model-based analysis and optimisation of (bio)processesZengyuan Wang
Department of Mathematical Modelling, Statistics and Bioinformatics

Coupure Links 653
B-9000 Gent (Belgium)
Tel.: +32-9-264.59.35
Fax: +32-9-264.62.20
E-mail: z
Education: Bio-engineer

Development and implementation of supervisory closed-loop control strategies for continuous manufacturing in the pharmaceutical industry


Traditionally, production of pharmaceuticals is realized using batch processing steps which can be fairly inefficient, time-consuming and poorly unscalable. Recent clarification by the regulatory authorities as well as the industry have accelerated the search for new manufacturing technologies. Consequently, a transition towards continuous manufacturing which includes real-time process monitoring and closed-loop control, has gained tremendous attention over the past few years. This because of the economic, environmental, safety and product-related advantages of a continuous manufacturing line. Driven by this change in mind-set, an innovative continuous direct compression line was developed for secondary manufacturing of pharmaceutical tablets.

Previous and current studies at this research group are mainly focusing on the development of advanced measurement tools, which allow for real-time monitoring, and first principle models to ensure an improved understanding of the different phenomena occurring during processing. Based on this knowledge a valid system-wide closed-loop control strategy, for the CM-DC, will be developed in this project.

This project is co-promoted by:

  • Prof. Dr. Thomas De Beer, Laboratory of Pharmaceutical PAT, Faculty of Pharmacy, Ghent University, Belgium.
  • Prof. Dr. Ingmar Nopens, BIOMATH, Faculty of Bioscience Engineering, Ghent University, Belgium.