Eline Teirlinck

Eline Teirlinck

 

 

 

 

 

Contact

Laboratory for General Biochemistry and Physical Pharmacy
Ghent University
Ottergemsesteenweg 460
9000 Gent
Belgium
Tel: 0032 9 264 80 47 (secretary)
Tel: 0032 9 264 80 49 (direct)

E-mail: Eline.Teirlinck@UGent.be

Biography

Education:

After obtaining her Bachelor degree in Pharmaceutical Sciences at the University of Ghent, she graduated in 2014 as a Master of Science in Drug Development. She wrote her Master thesis called ‘Dendrimersomes: a new entry in the field of nanosized MRI agents’ in the Molecular Imaging Center (Department of Molecular Biotechnology and Health Sciences, Torino), and became co-author of the article ‘Dendrimersomes: a new vesicular nano-platform for MR-molecular imaging applications’.

Scholarship:

Doctoral fellow of the Agency for Innovation by Science and Technology (IWT) since January 2015.

Research interests:

Biofilms, antimicrobial resistance, laser therapy, nanomedicine, vapour nanobubbles.

Summary of Research Project(s)


The widespread presence of antimicrobial resistance against typical antimicrobial agents is a well-known problem and is an important reason why treatment of these infections often fails. Micro-organisms can adhere on (a)biotic surfaces and encase themselves in a matrix composed of exopolysaccharides, proteins and extracellular DNA; this is a so-called bacterial biofilm.
One of the typical properties of biofilms is their decreased sensitivity to antimicrobial agents as compared to non-adhering cells. A crucial reason for this increased tolerance is the hindered diffusion of antimicrobial agents through biofilms. In this project the delivery of antimicrobial agents to biofilm cells will be improved in a two-step strategy in which the mechanical disruptive force of laser-induced vapour nanobubbles plays a central role:
1) Gold nanoparticles will be administered to biofilms and cell clusters will be disrupted by laser-induced vapour nanobubbles. Subsequent treatment with antimicrobial agents is expected to result in an improved biofilm destruction.

2) The second aim of this work is to create light-responsive carriers of antimicrobial agents by means of incorporating these agents into carriers such as liposomes and functionalize them with gold nanoparticles. Laser irradiation will be used to generate vapour nanobubbles for the disruption of biofilm clusters and to release the antimicrobial agents from the carriers close to the bacteria.

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