Laboratory of General Biochemistry and Physical Pharmacy

Molood Shariati

Molood

 

Contact

Laboratory for General Biochemistry and Physical Pharmacy
Ghent University
Ottergemsesteenweg 460
9000 Gent
Belgium
Tel: 0032 9 264 80 47 (secretary)
Tel: 0032 9 264 83 65 (direct)

E-mail:

Biography

Education:

2010-2013
Master’s degree student in Cellular and Molecular Biology-Genetics at Tarbiat Modares University. Tehran, Iran
(Master thesis entitled : Investigation of Dendrosomal Curcumin inhibitory effect on the Human Telomerase Reverse Transcriptase gene ( hTERT ) promoter through induction of TGFβ1 signaling pathway in hepatocarcinoma cell line (Huh7) )

Research interests:

Nanomedicine, nanoparticle-based drug delivery systems, Anti-cancer Agents, Chemotherapeutics 

Summary of Research Project(s)


1.    Exploring the interface between nanomedicines and aerosolization for intraperitoneal (IP) drug delivery:
Recent advances in intraperitoneal (IP) locoregional drug delivery strategies have opened the door to a minimally invasive, intra-abdominal aerosol-based localized therapy, known as pressurized intraperitoneal aerosol chemotherapy (PIPAC), which is regarded as a palliative therapeutic option for patients suffering from enhanced peritoneal carcinomatosis (PC). Over the past decades nanotechnology has created new therapeutic avenues for IP locoregional cancer therapies, by presenting new opportunities in this field ranging from sustained and/or stimulus-triggered release of therapeutic payloads in the peritoneal cavity for extended periods of time to NP surface modifications for targeted drug delivery towards specific tumor tissue within the peritoneal space. Accordingly, we have set out to explore the potential of IP drug delivery at the interface of nanotherapeutics and aerosolization approach, in order to gain an insight into the challenges and opportunities for future translation of this combinatorial therapeutic modality in the clinic. Different subtasks are as follows:
-    Investigation into feasibility and efficiency of IP administration of messengerMax/mRNA complexes through high pressure nebulization (i.e., PIPAC)

-    Studying the synergy between cisplatin-loaded polyarginine-hyaluronic acid nanoparticles (Cis-pARG-HA NPs) and IP nebulization approach for effective elimination of intra-abdominal metastases of advanced human ovarian cancer

-    Exploring the effect of geometry and size on the biodistribution of particulate delivery systems in the peritoneal space

2.    multiparametric mapping of vapor nanobody mediated photoporation for different cell types