Rein Verbeke

Rein Verbeke

Contact

Laboratory for General Biochemistry and Physical Pharmacy
Ghent University
Harelbekestraat 72
9000 Gent
Belgium
Tel: 0032 9 2648047 (secretary)
Tel: 0032 9 264 8074 (direct)
Fax: 0032 9 2648189
E-mail: Rein.Verbeke@UGent.be

Biography

Rein Verbeke graduated with a Master degree in Drug Development at the department of Pharmaceutical Sciences, Ghent University Belgium. For his Master’s thesis, he evaluated a theranostic perfluorocarbon particle for loading dendritic cells with antigen and to track them with 19F MRI. In 2013, he started his PhD research on nanovaccines for cancer immunotherapy in the lab of General Biochemistry and Physical Pharmacy. Besides its research activities, he is teaching assistant on the subject of Physical Pharmacy (Practical exercises).

Summary of Research Project(s)

Rein’s project focus in the development of a nanoparticulate based strategy for cancer immunotherapy. He aims to design a lipid-based nanoparticle that can be used for the delivery of antigen-encoding mRNA and immunostimulants to dendritic cells in vivo.

Rein Verbeke research project1


Dendritic cells (DCs) have the unique capacity to elicit antigen-specific immune responses, and therefore known as the orchestrators of the immune system. DCs continuously sample their environment, engulfing foreign material and presenting it on their surface to naïve T cells. Importantly, DCs can provide the necessary co-stimulatory signals to activate T cells and promote their differentiation into effector T lymphocytes.

By targeting this potent antigen presenting cells with a nanoparticle that contains both tumor associated antigens (TAA) and efficient immunostimulants, DCs can be modified to evoke specific anti-tumor immune responses.