Gut Alterations during Alcoholic Liver Disease

Gut-Liver Immunopharmacology Unit


Project 2

Gut Alterations during Alcoholic Liver Disease


Alcoholic liver disease (ALD) is one of the major causes of liver-related mortality worldwide. ALD can range from alcoholic steatosis to hepatitis and liver fibrosis and even to liver cirrhosis and fulminant liver failure. The pathogenesis is only partly understood but a disrupted intestinal barrier, increased gut permeability and associated bacterial translocation are important driving factors in the development of alcohol-induced liver disease. In this project, we will further investigate hepatic and gut alteration during the development of ALD and explore how we can interfere in this gut-liver axis as therapeutic strategy for ALD


Lindsey Devisscher