Analysis of DNA repair mechanisms

Within this line of research, the 'Radiobiology Research Group' investigates defects in DNA repair mechanisms that underlie radiation sensitivity in cancer patients (e.g. breast cancer) and patients with a congenital immunity error or DNA repair disorder (SCID, CID, Ataxia telangiectasia, Fanconi anaemia, ..).

Research projects

Relationship between radiosensitivity, DNA repair and breast cancer predisposition

Within this project, we research the involvement of breast cancer-predisposing genes (BRCA1, BRCA2, ATM, ..) in radiosensitivity.

 

Analysis of radiosensitivity in patients with rare disorders

Within this project, we analyze, among other things, the radiation sensitivity in patients with inborn errors of the immune system or DNA repair disorders.

 

Analysis of radiosensitivity in cancer patients undergoing radiotherapy

We are analysing the radiosensitivity in patients with different cancers: breast, ovarium, head and neck, brain, cervical, ...

 

Development and optimization of functional assays to assess DNA double-strand break repair capacity

Within this project, we investigate both homologous recombination and non-homologous end-joining in DNA.

 

Funding

Collaborations

  • National Reference Centre (NRC) for diagnostic radiosensitivity testing (approved by Sciensano) since 2019

 

Publications

Questions?

  • Anne Vral, full professor

+32 9 332 51 29

  • Ans Baeyens, associate professor

+32 9 332 49 19