Epidemiology and Prevention of Cardiovascular Diseases Unit: Projects

Clinical Research


The ASKLEPIOS Study

ASKLEPIOS is a longitudinal study following >2500 apparently healthy subjects from Erpe-Mere and Nieuwerkerken in Belgium. The study on this population sample (aged between 35 and 55 years at baseline) focuses on better risk prevention models (biomarker discovery & validation, screening), better understanding of cardiovascular function (imaging, heamodynamics) and better understanding of human aging (epigenetics).


In phase 1 of the study, conducted from 2002 to 2004, we screened a representative, random population sample of >2500 apparently healthy subjects from Erpe-Mere and Nieuwerken in Belgium. The subjects were extensively phenotyped including questionnaire data, echocardiography, vascular echography, arterial tonometry, and biochemistry (including inflammatory biomarkers, DNA and telomere biology and biobanking).
Phase 2 of the study is currently ongoing. After a 10 year follow-up, we are currently re-examining all 2500 subjects. The examinations will repeat all the phenotyping from phase 1 augmented with additional measurements: spirometry, sleep apnea testing, miRNA isolation, 3D echocardiography and cardiovascular measurements during isometric stress testing.