Genetics, sex steroids and their interactions in the regulation of bone metabolism in men

Staff

Y. Taes, J.M. Kaufman, S. Goemaere

Scientific collaborators
V. Bogaert, B. Lapauw, H. Zmierczak

A clinical investigation program by the Unit for Osteoporosis and Metabolic Bone Diseases (sections of Endocrinology and Rheumatology), the section of Endocrinology and the laboratory for Hormonology focuses on the study of the determinants of skeletal status in men, with particular attention for the interrelations between genetics, hormonal status, body composition and indices of muscle force. Recent/ongoing studies include:

  • a population based, prospective 4-year observational study in healthy men over 70 years of age in a semi-rural community (Merelbeke) on the determinants of sex steroid status and bone metabolism in elderly men, including the role of polymorphisms in candidate genes for regulation of sex steroid status and/or bone metabolism;
  • a genetic study of osteoporosis in men using a family-based approach in men with idiopathic osteoporosis and their relatives: detailed phenoptyping; association studies, genome-wide screening.
  • a study of the genetic determinants of sex steroid status and bone mass/metabolism in healthy young adult men using a sib-pairs approach population based recruitment of up to 500 pairs of brothers): association studies for candidate genes; preparation of a genome-wide screening.
  • studies of hormonal factors in secondary causes of osteoporosis in men: glucocorticoid-induced hypogonadism in osteoporosis, posttransplantation osteoporosis, growth hormone deficiency.

Cooperation

  • Dept. of Medical Genetics UGent
  • INSERM/Hôpital Lariboisière Paris: prof. M.C. de Vernejoul