Evidence Based Medicine Unit: Projects

Clinical Research


Systematic review of randomised and non-randomised clinical data

In an attempt to aid efficient integration of existing information and rational decision-making, we aim to produce summaries of the best available research on specific clinical questions, using transparent procedures to find, appraise and synthetize results of relevant research. We explore a wide array of topics within the field of clinical nephrology, dialysis and kidney transplantation with a focus on applied systematic review methodology on varying study designs. Our research activities occur in close collaboration with the Cochrane Renal Group.

Evaluating hospital care using registry data

The evaluation of care provided by hospitals is a complex issue, requiring relevant data on a representative sample of patients and choices concerning the targeted outcome, appropriate risk adjustment, final quality measure and benchmarks of interest. In this project we aim to study the value of combining different types of information sources in the context of acute stroke management: how much information can be gained through an investment in detailed records over and above the use of coarser measurements if and when readily available? This project represents a collaboration with the department of applied mathematics of Ghent University.

Guideline production

  • Management of diabetics with advanced kidney disease
  • Management of frail and elderly with advanced kidney disease
  • Pre-emptive transplantation
  • Management of Gitelman's syndrome
  • Factors influencing shared decision making

European Renal Best Practice (ERBP)

Our group has been actively involved in guideline development through European Renal Best Practice, the official guidance producing body of the European Renal Association – European Dialysis and Transplant Association (ERA-EDTA). The prime mission of ERBP is to improve the outcome of patients with kidney disease, and this in a sustainable way through enhancing the availability of the knowledge on the management of these patients in a format that stimulates its use in clinical practice in Europe. As part of this project, we define and expand guideline development methods, continue evaluating development procedures and support guideline development groups throughout the guideline development process. Prof. Wim Van Biesen is the current chair of ERBP.