Hemodialysis (HD) Unit: Projects

Kinetic modelling to optimise therapy

Kinetic modelling, describing the entire patient-dialyser system, is performed to unravel the behaviour of a large range of uremic toxins, i.e. how these solutes are distributed and transported in the deeper tissues where conceivably toxicity takes place. With the calibrated kinetic models, simulations of different dialysis strategies are executed to determine the optimal dialysis treatment.

    Uremic toxin removal/adequacy in HD

      In order to unravel the removal of different uremic solutes in the hemodialyser, different adequacy parameters are calculated with different dialysis modalities, e.g. hemodiafiltration with different dilution techniques, absorption, patient cycling during dialysis,...

      Evaluation of long term outcome regarding mortality and risk of chronic kidney disease after an episode of Acute Kidney Injury (FLAME-1  Flemish Acute Kidney Injury Medical Evaluation-1)

      Besides evaluating tools for early diagnosis of AKI, we are also interested in median and long term outcome data in critically ill patients who experienced an episode of AKI. Acute kidney injury is a known risk factor for later CKD development in settings outside the ICU. However, the risk of CKD after AKI in for example septic patients is more controversial and needs further investigation. Septic AKI is increasingly being recognized as a separate clinical entity with its own pathophysiology and clinical outcome.

      Anticoagulation in HD

      We developed a non-invasive, accurate and reproducible technique based on micro-CT scanning to quantify the degree of fiber blocking in a hemodialyser after use. In settings of different dialysers and/or anticoagulation strategies, different biochemical parameters and dialysis parameters are compared to the results of the micro-CT scanning.

      Dosing of antibiotics in HD patients

      Population Pharmacokinetics is performed to describe the distribution and transport of antibiotics in patients on hemodialysis. The validated models can further be used to personalise antibiotics dosing accounting for patient and dialysis characteristics.