Research projects - Radiobiology

Patient dosimetry and image quality in X-ray diagnosis

• Patient dose in C-arm cone beam computed tomography in interventional radiology and cardiology
• Impact of introduction of digital mammography on the performance of the Flemish breast cancer screening programme
• Individualized patient dosimetry and automated image quality analysis as tools for dose reduction in CT imaging
• Evaluation of patient dose and image quality in chest imaging with a human cadaver study
• Evaluation of dose reduction tools in contemporary CT imaging
• Evaluation and optimization of radiation exposure in hybrid imaging modalities in nuclear medicine
• Automated online staff dose registration in interventional cardiology
• Interventional cardiology procedures using a new generation flat-panel system: analysis of patient dose and image quality
• Image quality optimization in dental radiology

Biological effects of occupational, medical and accidental exposure to ionising radiation

EPI-CT: Epidemiological study to quantify risks for paediatric computerized tomography
• Direct assessment of low dose effects in children undergoing a computed tomography examination
• Mechanisms behind low dose effects in pediatric populations undergoing x-ray examinations
RENEB: Realizing the European Network in Biodosimetry
• CESI project: radiation effects in hospital workers (interventional cardiology, nuclear medicine) using biological and physical dosimetry
• Capacity building , education and training in Health related Radiation Biology through a North-South-South network in South Africa
MULTIBIODOSE: Multidisciplinary biodosimetric tools to manage high scale radiological casualties

Genetic basis of clinical radiosensitivity

• Validating predictive models and biomarkers of radiotherapy toxicity to reduce side-effects and improve quality of life in cancer survivors
• Predictive modelling for patient stratification according to treatment-related toxicity and survival after chemoradiation for head and neck cancer
• Genetic polymorphisms in miRNA genes and HPV status as biomarkers for response in oropharyngeal cancer patients
• Genetic polymorphisms as biomarkers for cachexia in head and neck cancer patients treated with radiotherapy
• Radiation-induced lung damage quantification with CT scans: Correlation with single nucleotide polymorphisms
• Prone IMRT for breast cancer: a new paradigm for avoiding side effects and radiation-induced malignancies ? The translational radiogenomics study

The role of DNA repair pathways in radiosensitivity and cancer predisposition and etiology

• Radiosensitivity analysis in patients with XCIND syndrome (ATM, NBS, SCID, ...) and breast cancer patients
• Development of radiosensitivity biomarkers in women candidate to early mammography screening, and investigation of underlying molecular determinants.
• Inherited predisposition for breast cancer in the next generation sequencing era: evaluation of the role of genes involved in homologous recombination and G2/M checkpoint control and development of a functional assay

Prostate cancer

• Role of non-neoplastic and preneoplastic lesions in the genesis of prostate cancer: a morphological study
• Detection and morphological characterization of non-neoplastic and preneoplastic lesions as a strategy to increase the specificity of prostate cancer diagnosis by magnetic resonance imaging and spectroscopy
• COCHRANE systematic review and meta-analysis research on the use of radio-isotopes and radiation for the treatment of advanced, deprivation-refractory prostate cancer