Publication highlights


  • De Jaeghere E, Denys H, De Wever O. Fibroblasts Fuel Immune Escape in the Tumor Microenvironment. Trends Cancer in press

Review focusing on the interaction between cancer-associated fibroblasts and immune cell in cancer patients.

First demonstration of recombinant extracellular vesicles as biological reference material for biomedical applications

Presentation of 8 focus points to bring extracellular vesicles into daily clinical practice

Depetter Y, Geurs S, De Vreese R, Goethals S, Vandoorn E, Laevens A, Steenbrugge J, Meyer E, de Tullio P, Bracke M, D'hooghe M, De Wever O. Selective pharmacological inhibitors of HDAC6 reveal biochemical activity but functional tolerance in cancer models. Int J Cancer. 2019 Aug 1;145(3):735-747


First demonstration of bacterial membrane vesicles in the systemic circulation of patients with reduced gastro-intestinal barrier function.

A 3D printed model moves a step closer to the accurate reproduction of peritoneal metastasis.

Findings reveal that paracrine IGF-1/IGF-1R signaling promotes colorectal cancer progression, establishing a preclinical rationale to target this activation loop.


EV-TRACK aims to increase standardization by establishing experimental guidelines and ensuring that they are met and transparently reported.

Review with focus on methodological issues in extracellular vesicle research.


This paper describes the first use of CAF as a deception tool to reduce peritoneal metastasis formation.

Review elaborating on the role of extracellular vesicles in physiology.


Adipose tissue is not an idle bystander but actively participates in cancer progression.

This research manuscript demonstrates the impact of different EV isolation methods on downstream omics analyses. This research manuscript formed the basis for the development of minimal experimental guidelines for EV research.

Review with focus on paracrine signaling in tumor microenvironment.


First demonstration of NRG1 derived from mesenchymal stem cells as driving contributor to cancer cell invasion, survival and poor prognosis in colorectal cancer patients.


First paper comparing longitudinal vs end-point assays for metastasis-related cellular activities.

Review elaborating on the definition and function of myofibroblasts in fibrosis and cancer.


Rab27B-mediated exocytosis is for the first time linked with invasive growth of breast cancer cells in cell culture experiments and patient samples.

This is the first review article describing the regulation of vesicular transport as a mechanism of invasive tumor growth and metastasis. In addition, we elaborate on the potential role of Rab27b in the release of extracellular vesicles.



Review with focus on function, diagnostic and therapeutic role of myofibroblasts in cancer.

Review elaborating on the therapeutic opportunities of targeting EMT during cancer invasion/metastasis.

Review elaborating on the important mechanism of EMT in cancer invasion/metastasis.


The first description of a molecular dialogue between colon cancer cells and myofibroblasts from the tumor environment.

First demonstration of the invasive capacity of myofibroblast in primary tumors, challenging the idea of who is invading who.


Review elaborating on tumor ecosystem concepts including the role of myofibroblasts.